thalassemia minor and covid immunity

FDA Approves First Cell-Based Gene Therapy to Treat Adult and Pediatric Patients with Beta-thalassemia Who Require Regular Blood Transfusions. Treatment is with corticosteroids. Daidone R, Carollo A, Perricone MP, Messina R, Balistreri CR. While it's always helpful to know your blood type, most people won't necessarily need to know that information. Key points about beta thalassemia in children. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Most people with beta thalassemia major have symptoms within the first 2 years of life. And people with some blood disorders like sickle cell disease are resistant to malaria, added Dr. Adalja. People with the most severe form of the disease may require regular blood transfusions. Beta-Thalassemia Minor and SARS-CoV-2: Physiopathology, Prevalence, Severity, Morbidity, and Mortality. With more research, we may one day have a clearer understanding of the connection between COVID-19 and different blood types. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. But its most common in the Mediterranean, where incidence can be as high as 15%. doi:10.1002/ajh.25857, NGO A, Masel D, Cahill C, Blumberg N, Refaiie MA. Sotiriou S, et al. (2022). If you have beta-thalassemia trait, you have a 50% chance of passing on the affected gene to any child you have. EHA and TIF explore how COVID-19 is affecting thalassemia and SCD Vitamin and mineral supplementation for -thalassemia during COVID-19 doi: 10.4084/MJHID.2023.007. Home isolation in transfusion-dependent thalassemia patients with SARS CoV2 infection: Experience from a developing country. (2022). Beta thalassemia is the most common blood disorder caused by a mutation in a single gene. Prevention measures are very important. 2020;15(1):265.doi:10.1186/s13023-020-01543-0, Piga A, Perrotta S, Gamberini MR, et al. Thalassaemia is the name for a group of inherited conditions that affect a substance in the blood called haemoglobin. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. The need for frequent blood transfusions and complications of the disease that result in more clinic visits and hospitalizations could raise the odds that someone would come into contact with the virus. Thalassemia may increase the risk of serious outcomes of COVID-19. Some researchers hypothesize that thalassemia might be protective against COVID-19 as it is against malaria. People with beta thalassemia minor can have anemia so mild they dont know they have it. Other types of thalassemia cause more severe symptoms that can be found earlier in life, usually before a child is . Frequency of COVID-19 Antibodies in Patients With Hereditary There are two types of thalassemia, alpha and beta. In late 2020, a team of researchers in the United States and Europe succeeded for the first time in using CRISPR to treat 10 people with sickle cell disease and transfusion-dependent beta thalassemia. (2022). The one gene defect, beta thalassemia trait (minor), is asymptomatic and results in microcytosis and mild anemia. 2020;60(12):3046-3054.doi:10.1111/trf.16056, d'argon A, Putri MG, Savitri Y, Alfaidin AMR. EHA and TIF Explore How COVID-19 Is Affecting Thalassemia and SCD Patients. They only have one mutated HBB gene from their parents. 2023 Jan 1;15(1):e2023007. Orphanet J Rare Dis. sharing sensitive information, make sure youre on a federal This shortage has been of even greater concern in South Asia (due to a high incidence of beta-thalassemia), where it's been estimated that 200,000 people depend on regular blood transfusions to manage their condition. Beta-thalassemia may protect against COVID 19 - Semantic Scholar According to this systematic-review meta-analysis, beta-thalassemia carriers could be less affected by CO VID-19 than the general population and more susceptible to die from COVID-19 or one of its consequences. Vaccination can help prevent COVID-19 infection and prevent severe illness if you do. While Health is trying to keep our stories as up-to-date as possible, we also encourage readers to stay informed on news and recommendations for their own communities by using the CDC, WHO, and their local public health department as resources. WHO COVID19 Dashboard. A Practical Approach to the Management of Cancer Patients During the Novel Coronavirus Disease 2019 (COVID-19) Pandemic: An International Collaborative Group. Read on to learn more about why its important for people with beta thalassemia to get vaccinated and why beta thalassemia may increase the risk of severe COVID-19 illness. Getting a COVID-19 vaccine can help people with beta thalassemia prevent severe disease and death. Telehealth visits, which are appointments with a healthcare provider using electronic devices from your home, are considered the equivalent of an in-person visit in many ways and can provide excellent care in many situations. What's the Link Between ARDS and COVID-19? Please enable it to take advantage of the complete set of features! The changing epidemiology of the ageing thalassaemia populations: a position statement of the Thalassaemia International Federation. 2021.doi:10.1016/j.htct.2021.04.003, Dalamaga M, Karampela I, Mantzoros CS. Many times people with thalassemia are prescribed a supplemental B vitamin, known as folic acid, to help treat anemia. The information in this article is current as of the date listed. Guidelines for the Management of Transfusion Dependent Thalassaemia, 3rd ed. People having hematological disorders and hypercoagulability state need extra precautions because of the increased risk of thrombosis after COVID-19 vaccination. In general, if both parents have thalassemia trait, theres a: Because more genes are involved in alpha-thalassemia trait, there are several possible outcomes depending on each parents combination of genes. Therefore, it is unknown if COVID-19 vaccines are as efficacious for patients with thalassemia as they were found to be for the clinical trial participants . According to this systematic-review meta-analysis, beta-thalassemia carriers could be less affected by CO VID-19 than the general population and more susceptible to die from COVID-19 or one of its consequences. Lets look at why and what you can do about it. Thalassemia is an inherited blood disorder that affects your body's ability to produce hemoglobin and healthy red blood cells. The site is secure. Getting COVID-19 offers some natural protection or immunity from reinfection with the virus that causes COVID-19.It's estimated that getting COVID-19 and COVID-19 vaccination both result in a low risk of another infection with a similar variant for at least six months.. The most important thing you can do is make sure you are vaccinated and stay up to date on when boosters are needed. Lack of hemoglobin can lead to insufficient oxygen in your bodily tissues. Anemia can affect your weight, whether due to its impact on your appetite and activity levels or its underlying cause. COVID-19 and thalassaemia: A position statement of the - PubMed The Link Between Blood Type and COVID-19 Risk - Health (2022). 1,5% global population . There are three types of thalassemia, one is minor and the other two Alpha and Beta thalassemia are a major threat to health of a person. (2020). Thalassemia trait means you carry the gene that causes the disease, but you dont have the disease yourself. "At the end of the day, we're still not sure if blood type makes a difference," said Dr. Russo. Doctors and researchers have looked at the evidence. The study from Iran found that having a diagnosis of thalassemia was associated with poorer outcomes, particularly for people who have complications of thalassemia. In that event, it's advisable that the therapy be stopped until the infection has cleared. Genetic testing is the only way to confirm whether you carry the gene. They result in low hemoglobin production and destruction of red blood cells. In thalassemia, the body is unable to make either alpha or beta chains in adequate amounts. Thalassemia: Complications and Treatment | CDC If youre a silent carrier or have thalassemia minor, youre unlikely to need typical thalassemia treatments, like blood transfusions or iron therapy. A few options include: Current recommendations are that for people who have been treated with Reblozyl, the medication should be continued even if a person develops COVID-19 (there is no evidence that it should be stopped).

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