I also recently found *another* article written by an endocrine surgeon Sam Wiseman from the Department of Surgery ,St.Paul's Hospital University Of British Columbia for the site Gland Surgery where he also points out real concerns that half of patients(as I said I know it's more,from all of the people I have found posting on thyroid boards) with benign nodules wrongly classified as "suspicious" by the Afirma test are getting unnecessary thyroid surgery because this Afirma result influenced a lot of endocrinologists and their patients to have the thyroid surgery! It was found incidentally in an MRI I had for cervical spine pain. Others understand my need for more information. 8600 Rockville Pike 2018 Jul;126(7):471-480. doi: 10.1002/cncy.21993. Thyroid Fine Needle Aspiration Biopsy (FNAB): Change In Thyroid Nodule Volume Calculator, Find an Endocrinology Thyroid Specialist, Clinical Thyroidology for the Public (CTFP). I had the ultrasound, and am waiting for my appointment with her to go over the images. I think my biggest problem is what I read on the internet as far as all the problems afterwards. Sometimes you only hear the bad stories and not the good so I wanted to share mine. So when I say the doctor's says suspicious for cancer with a 75% possibility, I'm not sure how she gets 'unlikely' from that. I welcome your thoughts on my case. Did your Afirma results show calcification? It's barely even hoarse. A month ago I had the Afirma test and it came back positive - suspicious for cancer which increased my chance from 5% to 50%. The Afirma GSC is designed to help clinicians manage these patients. The doctor uses a very thin needle to withdraw cells from the thyroid nodule. (Afirma GSC suspicious, suspicious for malignancy, or malignant cytopathology) ,2,4,8 I immediately started crying, knowing that a phone call wasn't "the good news." The . I don't know if I'm speaking too soon, but the pain isn't as bad as I thought it would be. I am so glad to find this as reading everyone's story helps me feel not so aloneTHANK YOU! Tumor is partially encapsulated with no capsular invasion or extrathyroidal extension identified. Choosing to have the surgery was the most difficult decision ever, since I wasn't sure if my nodule was cancerous or not, and of course I didn't want to go through the surgery all for nothing. The results of the GEC are either read as suspicious for cancer or benign. I wish you luck in whatever you decide. Afirma Gene Expression Classifier: a test for a group of molecular markers in thyroid biopsy specimens in order to determine the likelihood that a thyroid nodule is benign or cancerous. The Afirma Xpression Atlas for thyroid nodules and thyroid cancer At first it sounded like only the encapsulated variety was going to be included in the reclassification, but more recently it seems that non-encapsulated and non-invasive FVPTC is also going to be included. Third, I have no history of thyroid cancer (or any cancer) in my family. Veracyte Announces New Data Suggesting Afirma Testing Can Help HHS Vulnerability Disclosure, Help The https:// ensures that you are connecting to the Thanks. Paratracheal nodule (inclduing B1FS): Thyroid Parenchyma, negative for tumor. This study suggests that more research is needed to determine if the noninvasive follicular variant thyroid cancer can be diagnosed by molecular markers without proceeding to surgery. False positive rate of Afirma was 56% (32/57). Long-Term Outcomes of Thyroid Nodule AFIRMA GEC Testing and Literature Review: An Institutional Experience. The site is secure. I have bumps on my head that come and go and are considered normal, and another cyst on my arm that I've had since I was eleven -- also normal. Neither will talk to the other. I posted the below post on this forum on several different topics since 2013. Thyroseq v3, Afirma GSC, and microRNA Panels Versus Previous Molecular Tests in the Preoperative Diagnosis of Indeterminate Thyroid Nodules: A Systematic Review and Meta-Analysis. I had another biopsy which came back showing "Atypical cells". Thyroid nodules are commonly found on ultrasound of the neck and the evaluation of a thyroid nodule may include thyroid biopsy. -5.5cm x 3.9cm x 3.9cm Left Thyroid Nodule: Large mixed/mostly solid, isoechoic, ill-defined margins, macrocalcifications, taller-than-wide: TI-RADS 5 3. However, that information will still be included in details such as numbers of replies. Once you go down the hole, there are no good statistics to guide you in making rational decisions in an irrational area of medicine - AND as you know, no decisions in medicine in even cut and dried cases are so simple as to have no opposing point of view. The mindset of most surgeons is to cut it out - ignoring the risks of that approach. After some research of my own, I decided to leave it. NTRK, RET, BRAF, and ALK fusions in thyroid fine-needle aspirates (FNAs). But, I'm also tired of living with the uncertainty and semi-annual nerve sessions after each ultrasound. There was no follow up in 13% of cases and 87% were resected (50% lobectomies and 50% total thyroidectomies). I understand that Afirma tends to have a lot of false positives, but it's supposed to be fairly accurate for negative results. I didn't make a big deal about the cost because I am having surgery and they money I paid was my 20% co-pay and my out of pocket limit is almost met. I was informed in August of 2013 after a FNA that one of my nodules was suspicious and the recommendation was a TT.
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