However, further advancements in nanomedicine will provide breakthroughs that represent a paradigm shift in the treatment of cancer, and can significantly contribute to an improved patient outcome. The targeting of cells by nanoparticles results in highly specific delivery of cargos, resulting in high concentrations of the therapeutic within the cell. Carbohyd. 353(1), 2632 (2007), F. Zhao et al., Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials. 2023 Feb 26;15(3):774. doi: 10.3390/pharmaceutics15030774. Advances in Cancer Treatment - Springer There was a 27% increase in the cellular uptake of cells treated with magnetic mesoporous silica nanomaterials with epirubicin in the presence of external magnetic field when compared to free epirubicin [226]. B 3(39), 77247733 (2015), J. Zhang et al., pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities. 12, 14531464 (2017), X. Hua et al., Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment. Hobbs et al., Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Nanotechnology and Early Cancer Detection and Diagnosis - NCI Nanotechnol. Evaluating intrinsic and non-intrinsic cancer risk factors. Preprints 2021, 2021100407. J. Pharm. Proc. Lasic, D. Papahadjopoulos, Liposomes revisited. Chem. Keywords: The effectiveness of anticancer drug treatment can be achieved only when the administered drug is of proper dosage and display maximal activity in the cancer cells. Cell Cycle 8(22), 36153616 (2009), P.N. 11, 66936702 (2016), S.A. Sadat Shandiz et al., Novel imatinib-loaded silver nanoparticles for enhanced apoptosis of human breast cancer MCF-7 cells. Biotechnol. Targeting specificity and payload delivery capacity are two critical parameters required to optimize the efficiency and viability of a nanoparticle-based active targeted systems in in vivo settings. To develop nanomaterials for specific biomedical applications, surface chemistry design is indispensable. Eur. Moreover, nanomaterials can also be designed for increased drug loading, improved half-life in the body, controlled release, and selective distribution by modifying their composition, size, morphology, and surface chemistry. Nanotechnology for early cancer detection. Nanoscale 9(43), 1706317073 (2017), X. Xu, F. Hu, Q. Shuai, Facile synthesis of highly biocompatible folic acid-functionalised SiO2 nanoparticles encapsulating rare-earth metal complexes, and their application in targeted drug delivery. Uptake was less effective with the negatively charged particles, however, indicating the role of negative surface charge on the nanoparticles, which can reduce the undesirable clearance by liver cells [111]. In fact, significant strides have been made towards the application of engineered nanomaterials for the treatment of cancer with high specificity, sensitivity and efficacy. Bae, Drug targeting and tumor heterogeneity. Mater. Nanotechnol. Clin. 28(11), 28152822 (2017), V. Karthika et al., Biocompatible properties of nano-drug carriers using TiO2Au embedded on multiwall carbon nanotubes for targeted drug delivery. by A. Dhawan (CRC Press, Boca Raton, 2018), pp. ACS Appl. Multifunctional mesoporous silica nanomaterials have been employed to provide a synergistic blend of different assemblies into nanoplatforms with enhanced antitumor activity and less cytotoxicity to normal cells. Nanoparticles as a Delivery System of Antigens for the Development of an Effective Vaccine against. Nano Converg. Nanotechnology in cancer diagnosis: progress, challenges and opportunities In the fight against cancer, early detection is a key factor for successful treatment. Biol. In contrast, non-HER2 targeting moieties or non-targeted liposome nanoparticles resulted in the accumulation of particles in the perivascular and stromal space of the tumor site in higher proportion. Yao Y, Zhou Y, Liu L, Xu Y, Chen Q, Wang Y, Wu S, Deng Y, Zhang J, Shao A. Mater. Biotechnol. Despite the numerous advantages of the nano-based cancer therapeutics, clinical translation of these nanomedicines remains to be a challenging mission. Fuster MG, Montalbn MG, Moulefera I, Vllora G, Kaplan DL. They observed that this dual targeting system is more efficient in delivering Au nanoparticles to cancer cells than their corresponding single ligand system [54]. J. Pharm. Int. Carbon 107, 8799 (2016), Q. Zhang et al., Biocompatible, uniform, and redispersible mesoporous silica nanoparticles for cancer-targeted drug delivery in vivo. Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology. Researchers at Stanford University recently have been developing nanotechnologies that give both anatomical size and location of prostate cancer cells (nanobubbles for ultrasound imaging) and functional information to avoid overdiagnosis/treatment as well as to monitor progression (self-assemblying nanoparticles for photoacoustic imaging). CAS Nat. Cancer Res. Chem. The active targeting was achieved using cetuximab, an epidermal growth factor receptor (EGFR) monoclonal antibody, since epidermal growth factor receptor is highly expressed on the tumor surface of colorectal cancer cells. Cellular uptake of larger particles (50nm spheres and 40nm stars) was higher when compared to 13nm spheres, establishing that the size and shape of the nanoconstructs not only influenced the kinetics of cellular uptake but also affected intracellular distribution as depicted in Fig. Int. Int. Nanomed. Theranostics 8(3), 693709 (2018), G. Wang et al., Theranostic hyaluronic acid-iron micellar nanoparticles for magnetic-field-enhanced in vivo cancer chemotherapy. Rep. 8(1), 2907 (2018), S. Patra et al., Green synthesis, characterization of gold and silver nanoparticles and their potential application for cancer therapeutics. This alteration could cause nanoparticles to lose their specificity leading to sub-optimal localization in desired sites or at cellular targets. J. Pharm. Artif. J. Nanomed. Scale bar: 200nm (b); in vitro cytotoxicity effect of different nanocomplexes on C6 cells evaluated by CCK8 assay at various TMZ concentrations.
disadvantages of nanotechnology in cancer treatment
disadvantages of nanotechnology in cancer treatment