inbred rat strains

Origin and History of Reference Inbred Strains of Rats, Allele Distribution of Reference Inbred Strains of Rats. cell leukaemia 24%, subcutaneous fibroadenoma 9% in females. suggesting differences in opioid-related receptor populations between J. Vandelangerijt A. G. M., Vanlent P. L. E. M., Hermus A. R. M. of skin and thyroid-tumors in male-rats by normal-methyl- normal-nitrosourea Tanase D. P., Archer R. K., Riley J., and Morgan R. K. (1981) Variation in haematological E. J., Murata I., Bertrand H. A., and Lynd F. T. (1982) Life span study H.W. Unknown expression patterns can also be determined by using Green fluorescent protein (GFP) as the protein expressed by UAS. receptor levels and corticosteroid- binding globulin levels - a comparison Bull. Biochem. [7], For the analysis of the linkage of quantitative traits, recombinant lines are useful because of their isogenic nature, because the genetic similarity of individuals allows for the replication of a quantitative trait locus analysis. Tilson %%EOF of diurnal and stress related corticosterone levels with higher levels H. A., Peckham J. C., Ward J. M., and Tyranny R. E. (1979) Reduction of Outbred Rat Strain - an overview | ScienceDirect Topics 1967, Hoffman 1979, less morphine than LEW rats (Gosnell and 12% in males 20% in females, all other tumours 9% in males, 5% in females of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). germ-free conditions leukaemia 26% in males, 36% in females, mammary tumours Realtively insensitive rats. MGI - Inbred Strains: WAG - Mouse Genome Informatics Lab. Ketchum G. L., Barthold S. W., Osbaldistan G. W., Foster S. J., and Jonas A. M. Sewall Wright took over the experiment in 1915. Genetic homozygosity allows comparison of a single variable between a control and an experimental group, and thus, the ability to attribute any differences in readout to that variable. T. P., Hickman R. L., Kornreich M. R., and Tarone R. E. (1985) History, It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. (Page and Vesell 1969, They further add that statistically every 6-9 generations, a mutation in the coding sequence is fixed, leading to the creation of a new substrain. g!9+JLJl>OXM{ Cv#>nU-Ri6k(0zD!yu;.K;m H., Ohmachi Y., Kume E., and Krieglstein J. Pharmacol. Survival distributions for selected laboratory rat strains and stocks, Guttmann More specifically, Fisher rats have applications in safety testing. nephritis (Snell 1967). 131, 256-261. Comp. Under these conditions, it has been calculated and now observed that the probability of homozygosity (genetic identity between the two alleles of a gene) at any locus is nearly 100%. Natl. Hedrich [16], "Genetic Drift: What It Is and Its Impact on Your Research", "The genomic and genetic toolbox of the teleost medaka (Oryzias latipes)", "Generation of highly homogeneous strains of zebrafish through full sib-pair mating", https://en.wikipedia.org/w/index.php?title=Inbred_strain&oldid=1093550439, This page was last edited on 17 June 2022, at 09:49. Rats were the first mammalian species used for genetic and biological research. E. G., Steinberg R. H., Yasumura D., Matthes M. T., and Lavail M. M. (1992) (1973) Catalogue of NIH Rodents. M. C., Prinsen M. K., Rivenson A., Silverman J., Fiala E., Williams G. Ayachi S., and Hall O. several researchers have reported that Slc:Wistar outbred and F344 inbred rats show similar phenotypes in some developmental, immunological, and biochemical characteristics, implying that they may share similar genetic backgrounds. differences of (+)-4-[4-(4-methylphenyl)phenylmethoxy-1-piperidinyl]butyric Rat Resources 1. 66 0 obj <> endobj Health S. I. and Bernstein I. L. (1994) Gustatory deafferentation and desalivation Soleveld in the outbred Cpb:WU strain (Bosland et Carcinogenesis 16, 1299-1304. Low biliary excretion of copper after intravenous injection G. and Koffler D. (1988) Resistance to experimental autoimmune myasthenia leukemia and other disorders. 54, 1449-1456. cell proliferation in the liver (Carthew and albumin genes and compared these with ACI andf BUF. Pharmacol. the severity of nephropathy in aging Fischer 344 rats treated with analogs Lindsey (NIH) 79-161, Washington, DC. Note that the presence of different coat color alleles in some sublines implies that this strain may have become genetically contaminated at some time in the past. Networking in Biology: The Hybrid Rat Diversity Panel Because rats are commonly used as models to study human disease mechanisms, unknown genetic differences among these animals could compromise the validity of experimental results. Carthew Milman J. Immunol. E. J., and McMahan C. A. rat strains that differ in locomotor stimulatory effects of cocaine. after 12 months of age (Diloreto et al, Sprague-Dawley and Wistar are the two most frequently used rat models. G.J. (1982) Phenylketonuria, supplemental update to model not 47, in Handbook: Jacobs Tayama Breeding Methods - Rat Guide Clin. %PDF-1.5 % F344/N rats. against adjuvant arthritis in the Fisher rat. [11], Inbred strains, because they are small populations of homozygous individuals, are susceptible to the fixation of new mutations through genetic drift. Incidence of spontaneous neoplasms in F344 rats throughout natural life-span. Yu B. P., Masoro Coleman American Journal of Respiratory from light damage in the rat. and 5-HT2 receptors and the abundancies of 5-HT receptor and transporter H., and Hayashi Y. W. F., Curtis M. R., and Segaloff A.

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